Gli3 is required for the specification and differentiation of preplate neurons
نویسندگان
چکیده
منابع مشابه
Gli3 is required for maintenance and fate specification of cortical progenitors.
Gli3, one of three vertebrate Gli transcription factors in Hedgehog (Hh) pathway, is processed into a repressor form (Gli3R) in the absence of Hh signal and acts as the major negative transducer of the pathway. Although the role of Gli3 in embryonic patterning has been extensively studied, its role in cortical neurogenesis, especially in the regulation of neural progenitors in proliferation and...
متن کاملTbr 1 Regulates Differentiation of the Preplate
the preplate into superficial and deep components, * Nina Ireland Laboratory of thereafter termed the marginal zone and subplate, re-Developmental Neurobiology spectively (Allendoerfer and Shatz, 1994). The cortical Department of Psychiatry plate grows in an " inside-out " order, from layer 6, which University of California, San Francisco contains the earliest-born cortical plate neurons, to la...
متن کاملFezl Is Required for the Birth and Specification of Corticospinal Motor Neurons
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown. Here, we report that Fezl is required for the specification of corticospinal motor neurons and other subcerebral projection neurons, which are absent from Fezl null mutant neocortex. There is neither an increase in cell death in Fezl(-/-) c...
متن کاملFgf16 Is Required for Specification of GABAergic Neurons and Oligodendrocytes in the Zebrafish Forebrain
Fibroblast growth factor (Fgf) signaling plays crucial roles in various developmental processes including those in the brain. We examined the role of Fgf16 in the formation of the zebrafish brain. The knockdown of fgf16 decreased cell proliferation in the forebrain and midbrain. fgf16 was also essential for development of the ventral telencephalon and diencephalon, whereas fgf16 was not require...
متن کاملCdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.
Blastocyst formation marks the segregation of the first two cell lineages in the mammalian preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the trophectoderm (TE) that gives rise to the trophoblast lineage. Commitment to ICM lineage is attributed to the function of the two transcription factors, Oct4 (encoded by Pou5f1) and Nanog. However, a positive regula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2005
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.08.033